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Being a natural athlete I’ve always sought to find more ways to increase testosterone levels naturally. The question I’ve always asked myself was what are the variables, which determine how much testosterone is boiavailable. I’ve read articles before, giving some advice on what in my every day life causes my test levels to go up and what causes them to go down. But after an extensive research I couldn’t find an article, explaining in detail how and actually what exactly I should manipulate directly in my system to achieve the effects I desired – namely not only higher levels of circulating testosterone but also how much of it will be available to the corresponding receptors in the cell walls. Moreover, I wanted to know all this in regards to natural bodybuilding… So, I decided to do some good digging and reading and then if I manage to put things together, to lay that in writing form so that others can benefit as well. Without wasting even a minute more I will start this off by describing what testosterone is and what it does in the human body. Testosterone is a steroid hormone with anabolic and androgenic properties. It is the main hormone, responsible for the increase in lean muscle tissue, increased libido, energy, bone formation, and immune function. Testosterone is secreted in the testes in men and in the ovaries in women. Small amounts are also secreted in the adrenal glands. Testosterone is derived from cholesterol. The levels of testosterone in men range between 350 and 1,000 nanograms per deciliter (ng/dl). After the age of 40 these normal levels start dropping by roughly 1 per cent a year. In the blood stream testosterone circulates in great percentage bound to so called binding proteins. Sex Hormone Binding Globulin or SHBG is the one that concerns us the greatest. Why? Because this is the main reason why testosterone might not be available to reach the cell receptor. When testosterone gets attached to SHBG, it is no longer able to perform its anabolic functions. What elevates SHGB: Anorexia nervosa, Hyperthyroidism, Hypogonadism (males), Androgen insensitivity/deficiency, Alcoholic hepatic cirrhosis (males), Primary biliary cirrhosis (females). What suppresses SHGB: Obesity, Hypothyroidism, Hirsutism (females), Acne vulgaris, Polycystic ovarian disease, Acromegaly, Androgen-secreting ovarian tumors Less than 1% of the circulating testosterone is in a free form in males (less that 3% in females). Only when in a free form this hormone can exhibit its properties by connecting to the androgen receptors on the cell walls. Based on a study 14 to 50 per cent of the testosterone is bound to SHBG in males and 37 to 75 in females. It is worth mentioning that SHGB poses very high affinity for binding to testosterone. Therefore, changes in the SHGB levels noticeably influence the level of bioavailable testosterone. Let’s discuss for a moment what exactly a testosterone bioavailability is. Other than SHGB there are two more testosterone-binding proteins, also called carriers. One of them is albumin. It is a low-affinity binding protein, thus testosterone bound to it is considered “bioavailable”. Albumin binds to testosterone in the range 45 to 85 per cent in men (25 – 65 in women). The third carrier is the cortisol binding globulin, which binds also with low-affinity to less that 1 % of the testosterone in circulation. The free androgen index (FAI) indicates the amount of bioavailable testosterone. FAI is the sum of the free testosterone and the albumin and cortisol binding globulin. Or it’s the total serum testosterone minus the SHGB-bound testosterone. It is now clear why we should focus our attention on the properties of SHGB. The levels of this binding protein increase when there is excess estrogen present. Conversely, SHGB levels drop if the testosterone levels are elevated. Here I should mention the fact that SHGB exhibits higher affinity to testosterone than to estrogen. Now, pay close attention… It’s a well-known fact that testosterone is an estrogen precursor – it will convert to estrogen under the influence of the enzyme aromatase. Nothing that we don’t know so far. Here is where it gets interesting. Suppose that we have normal testosterone levels and we don’t suffer from any of the health ailments, which influence the SHGB levels. That means that SHGB levels are normal, too. Bare with me now. If more of this testosterone is converted to estrogen due to abnormal aromatase levels, the SHGB I will increase as well. SHGB, being more readily bound to testosterone, will leave us with excess estrogen levels in the system, which in turn will stimulate increased production of the SHGB protein from the liver. This whole process ultimately amplifies estrogen levels. Estrogen readily binds to the androgen receptors in cells thus leaving less opportunity for the free testosterone. Even more important, estrogen is the messenger molecule that signals the brain to decrease testosterone production. Another thing of great importance is the fact that over 40 per cent of the SHGB protein circulates unbound in the blood stream in man (over 80 per cent in women), and albumin circulates unbound almost all of the time. Thus increase in the total testosterone levels does not produce any noticeable changes in the free testosterone levels unless there is a significant increase like the one seen after synthetic steroid hormone administration. Well, this whole story brings us to the conclusion that the main approach should be - to keep the testosterone bioavailability high. In this regard a natural athlete should strive to: · Prevent testosterone levels from getting low · Attempt to increase the total testosterone as a means of keeping the testosterone levels from plunging · Block the testosterone-binding effects of SHBG · Lower the levels of the enzyme aromatase - less testosterone conversion to estrogen 1. How to prevent testosterone levels from getting low? - Obesity. Based on the way the testosterone-estrogen mechanism works, increased levels of estrogen will ultimately decrease the circulating testosterone. Excess fat causes more estrogen production due to the fact that fat cells are those, which manufacture estrogen. So, the more fat cells, the more estrogen in the blood and the less testosterone. - Drug and alcohol abuse. Alcohol has the property to inhibit your ability to remove estrogen from the blood stream by acting as a central nervous system depressant and also by decreasing zinc levels. - Stress elevates corticosteroid levels in the blood steam, which causes the testosterone levels to decrease. - Medications. Some medications, including estrogen and progesterone, lower the lutenizing hormone (LH) levels. LH is the hormone, responsible for the steroid hormones production. - Diabetes. Studies suggest that there is a link between type 2 diabetes and lower testosterone levels. - Hypertension and high cholesterol levels. These both cause the arteries to harden, this way decreasing the blood flow to the sex hormone producing organs. That of course leads to low sex hormone levels. - Aging. Fact is after the age of 40 test levels drops by roughly one per cent per year. We can’t do too much about that. The clock keeps ticking for all of us. However, we can try to manipulate testosterone levels in any other possible way. - Low fat diet. Low fat consumption causes increase of the SHGB, which means one thing – less free testosterone. It is considered that monounsaturated fats play an important role in testosterone levels and bioavailability. - Overtraining can contribute to as much as 40 per cent drop in testosterone levels. That is why it’s important to notice early the signs of overtraining and give the body a week or two well-deserved rest. - Not enough sleep. If you are not getting enough sleep the body is not recuperating well, which causes less testosterone and more corticosteroids to be released. Just to mention corticosteroids like cortisol are in fact catabolic hormones meaning they use up muscle tissue to provide the brain and the heart with energy. - Vitamin C. It suppresses the release of the stress hormone cortisol. Cortisol decreases testosterone levels. So, ultimately less cortisol, more testosterone. 2. How to boost testosterone levels - Incorporate basic movements that involve several muscle groups in your training routine. Good ones are squats, dead lifts, and military presses. Basic (compound) exercises have been shown to play an important role in the testosterone levels. - The greatest workout related testosterone production occurs with the use of heavier weights and lower rep range. A study shows that the best is 85 per cent of your one-rep max. - Tribulus terestris is a natural supplement, which has been shown in some studies to have the ability to increase the leutenizing hormone (LH) levels. As we already mentioned above, one of the functions of LH is to stimulate testosterone production by the testes. 3. Block the testosterone-binding effects of SHBG - Nettle root as a highly concentrated extract has shown to be effective at binding to SHBG and therefore it permits more free testosterone to circulate the system. It also acts as a 5-alpha reductase inhibitor. This is the enzyme, responsible for the conversion of testosterone to dihydrotestosterone (DHT), a more potent form of the male sex hormone, which causes prostate enlargement and ultimately cancer. Methanolic extract of nettle can also cut down the SHBG levels, which is another form of elevating the free testosterone in the blood stream. - Pygeum (prunus africana) is another herb, known to block the testosterone-binding effects of SHBG. Nettle root and pygeum extracts also benefit the prostate gland as a preventive treatment for benign prostatic hyperplasia (BPH) both by blocking the 5-alpha reductase action. - Avena Sativa is an extract from the straw of oats. It has somewhat different properties. It works by freeing bound testosterone, which increases the free testosterone in circulation. 4. Lowering aromatize levels - Zinc. The mineral zinc inhibits the aromatase enzyme that converts testosterone into excess estrogen. The recommended dose for inhibiting aromatase is 80mg daily. However, be sure the combined zinc quantity of all the daily supplements you are taking does not go over this benchmark. - Chrysin is a bioflavonoid that has shown a potential as a natural aromatase inhibitor. Chrysin is poorly absorbed in the system. It is found that when taken along with piperine, chrysin exhibits a lot better absorption. Supplementation with chrysin and piperine together might bring good results in reducing aromatase levels. How does this all apply to the sport of natural bodybuilding Let’s assume you are an individual, who exercises regularly and who doesn’t consider taking exogenous steroid hormones. With other words you are a natural athlete or enthusiast, who desires to keep his natural testosterone levels in the range, favoring good health and lean muscle mass build up. Here is what you do: 1. If you are even slightly overweight consider staring immediately a diet and training routine, tailored toward fat loss and lean muscle retention. 2. Consider also dropping the alcohol intake to absolute minimum if you want your efforts in keeping test levels high to give results. 3. Begin mastering some types of self-control or even meditation. These will take care of the excess stress levels. 4. Take medications only if they are absolutely essential for your health and are prescribed by your doctor. Talk to your personal physician to find out if there are any natural remedies to replace your current medications and if he recommends such approach for your health issue. 5. Keep your blood pressure and the serum cholesterol in check. 6. Eat enough good fats in your diet. Good means monounsaturated and omega-3 and 6 polyunsaturated fats. 7. Don’t ever overtrain. Sleep enough to promote good recovery. Signs of overtraining are loss of appetite, tiredness and irritability, lack of motivation, impaired mental focus, prolonged recovery periods. 8. Start relying more heavily on basic exercise movements. Train in the low rep range most of the time. 5 – 8 reps will ensure that you’re using weights that will eventually stimulate elevated testosterone levels. 9. It will only do you good if you decide to try some or all of these natural supplements: chrysin - piperine blend, nettle root extract, pygeum, avena sativa extract, and tribulus terestris. Try to find them in your local health store. Follow the directions for best results. 10. And you shouldn’t even consider training without supplementing your diet with enough vitamin C (at least 1g a day) and zinc (15mg min.). Take vitamin C with your multivitamin formula after breakfast, and post-workout with your protein shake. Zinc should be present in your multivitamin blend but this is not enough. Take zinc with magnesium in the form of ZMA right before you go to bed on an empty stomach. References: Ron Geraci, Men's Health, December 25, 2000; 13 Ways to Naturally Boost Your Testosterone Levels LE Magazine January 2000; Replenish Testosterone Naturally Plant extracts favorably alter hormone metabolism and improve sexual desire in men Jennifer A. Kelly, Ph.D. and Leo Vankrieken, Eur. Eng. Diagnostic Products Corporation; Sex Hormone Binding Globulin and the Assessment of Androgen Status Cockatoo.com; Avena Sativa - are oats an aphrodisiac? Gabe Mirkin, M.D.; High Cholesterol Causes Low Testosterone Bodybuilding.com, Chrysin Info And Products - Block Estrogen, Increase Testosterone easy enlargement free pennis surgery way pro solution wealth penis enlargement pic home penis enlargment free penile enlargement technique free exercise tip for penis enhancement homemade pennis enlargement penis enhancement video
Steroids may be administered into the body by two primary methods: orally in tablet form, or by intramuscular injection with a needle. Some common examples of orals include oxymetholone (Anadrol), oxandrolone (Anavar), methandrostenolone (Dianabol), and stanozolol (Winstrol). Some of the more popular injectables include nandrolone decanoate (Deca-Durabolin), nandrolone phenpropionate (Durabolin), testosterone cypionate (Depo-Testosterone), and boldenone undecylenate (Equipoise). Many bodybuilders don’t just use one steroid but typically combine both oral and injectable drugs in what’s called a cycle, generally lasting 6- to 12-weeks. Injectable steroids are more popular because they are less toxic to the liver than oral steroids (orals have been chemically modified to survive passage through the digestive system). On the other hand athletes in drug-tested sports prefer orals as these drugs tend to clear more rapidly from the athletes’ systems and allow them to stand a better chance of passing a drug test. The practice of using more than one steroid at once is called "stacking," and the pattern of increasing the dosage during the cycle is referred to as "pyramiding." Some users take dosages of 50 to 100 times greater than the recommended medical dosages. The purpose of stacking and pyramiding is to maximize the muscle-building effects and minimize side effects. The fact that this practice has not been proven scientifically has not stopped bodybuilders from following such dosing patterns. Steroid side effects – the contentious issue! No drug is free from producing side effects, and steroids are no exception. Still, most of the ghastly side effects frequently reported by the media are greatly exaggerated either for political reasons or out of ignorance. While it’s true that a few steroid users may suffer serious side effects, the fact is, most do not. Put another way, millions of people have used these drugs for muscle building since the late 1950’s. If they were the cancer-causing, terminal illness-producing drugs, as commonly reported by the media, we’d expect an epidemic of dead and dying bodybuilders and other athletes. The fact that this is not happening should indicate just how much misinformation has been circulating on this issue over the past number of years. Most of the side effects produced can be divided into wanted and unwanted. For bodybuilders and other athletes such “side effects” as increased muscle size and strength, decreased body fat, and increased aggression levels, are the primary reasons why they turn to steroids in the first place. These are the wanted and desired side effects and the more pronounced these effects are the more bodybuilders like it. The unwanted side effects are those that get heavy coverage in the media and by anti-steroid groups. Most of the following side effects can be termed cosmetic and are not life-threatening. They’ll usually disappear with termination of steroid usage. A few, such as gynecomastia, are more serious and should be brought to the attention of a physician. In most cases serious side effects are caused by steroid abuse - megadosing and stacking the drugs for years. 1) Acne 2) Hair loss 3) Gynecomastia (feminizing of the male nipple region) 4) Water retention 5) Deepening of voice in females 6) Clitoral enlargement in females 7) Liver enzyme abnormalities 8) Decreased production of sperm in males 9) Decreased natural production of testosterone in males 10) Increased blood pressure 11) Reduction in HDL the "good" cholesterol Types of Steroids Since their first synthesis in the late 1950’s there have been hundreds of different varieties of anabolic steroids produced. The following shows a few of the more popular steroids used by bodybuilders for muscle building. Keep in mind that since the Anabolic Control Act of 1990, most of these drugs are now only available on the blackmarket and as such, the prices will fluctuate on an almost weekly basis. enlargment manhattan penis surgeon com enargement penis penis pump guide to penis enlargement vimax penis enlargement result buy penis enlarement pills com enlarement penis penis pump vimax customer service best penis elargement vimax natural penis enlargement and lengthening
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Flax is a plant that has been recognized since people first started to cultivate plants and flax has lent its unique properties to humankind for a great chunk of our history. The uses of flax are numerous and included cooking oils, seed and strong durable cloth. Medically, it was initially used to help cure coughs although recent research suggests that flax may have more application in treating and preventing prostate and breast cancer, and keeping arteries clear Flax seed is rich in alpha linolenic acid, an omega-3 fat that has anti inflammatory properties. Specifically it is the flax lignans, these are fibers found in flax that are thought to contain the therapeutic agents. Other plants contain lignans such as these but none are as rich a provider as flax. Hormones and Cancer Sex hormones including estrogen and testosterone, important in libido and reproduction can go out of balance and stimulate the overgrowth of breast or prostate tissue, which can have important consequences for cancers of this type. Lignans act as phytoestrogens, naturally occurring compounds that have a similar action to estrogen in the body. When phytoestrogens are ingested, the body transforms them into a form that keeps hormones from over stimulating cells, thereby helping to support normal cell growth. Lignans are also thought to interfere with the enzymes that promote development of cancer. Epidemological studies of populations that eat a lot of lignan suggest that this aspect of their diet produces lower breast cancer rates, and preliminary research suggests that increased lignan intake may act to protect breast tissue against cancerous growths. In a study published in 20001 women that were newly diagnosed with breast cancer and ate a significant amount of flaxseed every day showed reduction in the growth of cancer tumors. Numerous animal studies have shown similar findings. Lignans are important compounds in the body’s fight against free radicals, the highly reactive substances that are created in many of the processes in the body and are implicated in cancers, heart disease and many other disorders. Lignans essentially mop up these free radicals, restricting their negative effect on our bodies. Flax also has a positive effect on hormones and the substance appears to counter the effects of stress. One study2 of post-menopausal women showed that the participants who are the most lignans in their diet experienced the biggest fall in stress hormone levels and blood pressure Flax, Men and Prostate Cancer Studies have also shown huge health benefits of lignans for men. Prostate cancer is one of the most common cancers known and prostate cells can be influences by hormonal changes in very negative ways. An early study has suggested that flax lignans, in combination with a low-fat diet, may reduce the risk of prostate cancer. In the Duke University study, 25 men with prostate cancer were fed large doses of flax. All subjects experienced reduced hormone and cholesterol levels, and the tumor progression was slower3. The benefits of flax for men do not end here. The plants ability to moderate the male hormone testosterone has many positive indications. Animal studies have suggested that flax can reduce prostate enlargement, although not related to prostate cancer, it is an uncomfortable condition that affects many aging men. Additionally flax lignans interfere with DHT, a form of testosterone that can attack hair follicles and cause unwanted oil production in the skin, thus helping to prevent acne and hair loss, conditions dear to any teenagers heart. Flax has been a mainstay in the background of human development for a long time and with mounting evidence that of the medicinal benefits of flax, it looks like it will be around for a lot longer.